| Sikora (12,162) | Siler (25,879) | Sill (13,814) |
| Sills (20,692) | Silva (404,501) | Silveira (10,276) |
| Silver (77,498) | Silverman (66,734) | Silvers (22,894) |
| Silverstein (23,984) | Silvey (11,707) | Silvia (21,203) |
| Sim (10,328) | Simmon (10,649) | Simmonds (12,345) |
| Simmons (810,296) | Simms (115,557) | Simon (265,930) |
| Simonds (22,356) | Simone (20,014) | Simons (134,774) |
| Simonson (32,334) | Simpkins (39,935) | Simpson (690,631) |
| Sims (402,583) | Sinclair (99,568) | Sing (12,374) |
| Singer (99,521) | Singh (246,133) | Singletary (33,106) |
| Singleton (189,974) | Sink (20,271) | Sipe (20,902) |
| Sipes (20,369) | Sisco (23,420) | Sisk (39,197) |
| Sisson (45,329) | Sites (15,520) | Six (10,126) |
| Sizemore (39,796) | Skaggs (54,690) | Skeen (14,694) |
| Skelly (22,410) | Skelton (51,374) | Skidmore (38,786) |
| Skiles (15,109) | Skillman (10,212) | Skinner (226,830) |
| Skipper (28,208) | Slack (55,495) | Slade (45,021) |
| Slagle (28,138) | Slate (17,968) | Slater (132,292) |
| Slaton (15,529) | Slattery (38,171) | Slaughter (103,341) |
| Slavin (14,018) | Slayton (20,067) | Sledge (22,887) |
| Sleeper (11,491) | Sloan (177,950) | Sloane (12,255) |
| Slocum (41,532) | Slone (30,669) | Slusher (12,442) |
| Slusser (10,303) | Sly (11,560) | Small (204,732) |
| Smalley (44,143) | Smalls (28,441) | Smallwood (60,230) |
| Smart (94,900) | Smedley (15,360) | Smeltzer (11,827) |
| Smiley (68,789) | Smith (11,788,706) | Smithers (11,541) |
| Smithson (23,548) | Smock (16,845) | Smoot (30,627) |
| Smothers (21,808) | Smyth (35,878) | Smythe (14,587) |
| Snapp (14,717) | Snavely (11,555) | Snead (34,186) |
| Sneed (56,183) | Snell (95,283) | Snelling (12,916) |
| Snelson (15,155) | Snider (155,696) | Snipes (23,571) |
| Snodgrass (56,067) | Snook (26,734) | Snow (202,648) |
| Snowden (39,072) | Snyder (765,301) | Soares (20,472) |
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